Uridine is considered to be one of the most popular nootropics at the present time. Not only is it a very potent supplement but is also regarded to be one of the safest since it is already a naturally occurring substance in the liver. Being a nucleoside which consists or Uracil and D-ribose, Uridine is an integral component of our body’s RNA or Ribonucleic Acid. Uridine works in different ways in delivering its cognitive benefits. Although some dietary sources contain Uridine such as broccoli, tomatoes and beer, supplementation of Uridine will surely put you into the next level of cognitive performance. Let us now know how Uridine works in our body and why it is an important component in every stack.
As mentioned earlier, Uridine is one of the basic components of RNA or Ribonucleic acid. But what is its relation to a person’s cognitive function? Basically, RNA translates instructions from the DNA onto proteins. RNA also plays a vital role in what is called the Long Term Potentiation. Long term potentiation refers to the long-term strengthening of the synapses within the brain. These synapses are responsible for the efficient communication and signal transmission between neurons (3). When these synapses are strengthened, there will be a more efficient and effective transfer of impulses to and from the brain. Also, when storing memories in our brain a large quantity of RNA will be needed. Now with the supplementation of Uridine, it directly influences an increase in RNA since the former is a basic component of the latter. As a result, there would be a faster processing speed as well as improved cognitive function. There would also be an improvement in memory formation and retention as well. In contrast to that, lower levels of RNA and Uridine results in poor memory.
Another mechanism in which Uridine enhances cognitive function is through an increase in the production of Phosphatidylcholine. Phosphatidylcholine has been found to help elevate choline levels in the brain. This then, stimulates an increase of the neurotransmitter Acetylcholine. Because of this, there would be an enhanced cognitive function as well as improved focus and attention span. Moreover, Phosphatidylcholine also helps with the operation of the cells as well as the proper regulation of enzymes in the brain. Another effect that Phosphatidylcholine provides is the increased production of neurites. Neurites refer to any projection in the brain, either as an axon or a dendrite, which is involved in the transmission of signals to and from the brain (4). With an increased network of connections, there would be more room for the transfer of impulses and will lead to an improved synaptic plasticity. As a result, there would be greater memory retention and cognitive performance.
Once in the brain, Uridine is converted into another potent substance which is CDP Choline. CDP Choline or Citicoline, is a substance that serves to increase Acetylcholine levels in the brain. And as we all know, Acetylcholine is the neurotransmitter responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (1). Because Uridine increases the levels of Acetylcholine through the conversion into CDP Choline, the result will be an enhanced cognition. This includes increased learning ability, enhanced memory formation, storage and recall, improved attention span and focus, and faster processing speed.
Due to the influence of Uridine on the Cholinergic system, it has been shown to be a promising supplement that will aid in certain cognitive problems such as dementia, Alzheimer’s disease and other degenerative conditions.2. Uridine for mood
It has been found that Uridine serves to influence the Dopaminergic system by increasing the Dopamine levels. Dopamine is the neurotransmitter responsible for an individual’s memory and learning capabilities, attention, pleasurable reward, behaviour and cognition, and most especially for mood and sleep (2). With an increased level of this neurotransmitter, there will be a significant improvement in one’s mood and sleeping patterns. It may also be of great help to deal efficiently with stress, anxiety, depression, and even signs of OCD or Obsessive Compulsive Disorder.
It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Uridine, how much of it do we really need each day? The recommended daily dosage of Uridine would be between 500 mg to 2 g. However, some believe that taking 1 g of Uridine daily may be the average dose for attaining significant cognitive benefits. The daily dose may then be divided and taken into multiple administrations daily if you wanted to have a more constant and sustained release of Uridine effects.
When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.2. Stacking Uridine
Stacking has been a popular practice nowadays. This is done for the purpose of maximizing a drug’s potential and also, in order to yield more positive effects, to synergize each other, or to eliminate or minimize the side effects that the drugs may provide. With the case of Uridine, what drugs and supplements are best to use in conjunction to it? To maximize Uridine’s full potential, it would be best to stack it with a good quality Choline source such as Alpha GPC, Citicoline, Centrophenoxine among others. With the presence of a choline supplement, it will potentiate Uridine’s cognitive benefits thus providing a more potent combination. Moreover, adding another potent nootropic may significantly put you into a higher state of cognitive functioning. You might want to stack Uridine and a good choline source with a Racetam such as Phenylpiracetam. With Phenylpiracetam at hand, it may deliver and potentiate the other drugs’ cognitive effects at a faster time. Not only that, Phenylpiracetam serves to provide a boost in both mental and physical energy. As a result, this stack would surely work wonders as it will not only improve cognitive and physical performance but also serves to improve your mood, motivation, and concentration.
Aside from the nootropics mentioned above you might also want to stack Uridine with some other potent nootropics. This may include, but are not limited to Noopept, Pramiracetam, Adrafinil supplement among others.
Having a thorough understanding of the drugs you wanted to have in a stack is important because some drugs might not go well with the others. Stacking supplements greatly depends on your needs and personal preferences however, it would be best to consult your doctor or healthcare provider first.
Uridine is considered to be one of the safest supplements to be taken and is also well-tolerated. However when taken beyond the recommended dosage, it may produce some mild effects such as headaches, nervousness, fatigue, and gastrointestinal problems.
You can purchase Uridine online. Drug is available over the counter and thus, does not require prescription from a doctor. It is readily available in Uridine capsule or powder form. If you wanted an easier administration, you may take Uridine capsules. However if you wanted to save more from your money, you may opt to buy Uridine powder in bulk. Either way, both forms serve to deliver the same benefits. Purchase Uridine and experience a significant boost in your mood and cognitive performance.References: