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Sulbutiamine Review

Sulbutiamine Review Commonly sold under the brand name "Arcalion" is derived from two Thiamine (Vitamin B1) molecules synthetically bonded together helping it effectively cross the blood-brain barrier. This supplement is important for proper energy metabolism and improved nerve transmissions within the body's nervous system. It also has been thought to improve conditions such as chronic fatigue. Nootropic wise, it increases both memory and alertness by acting on dopamine and glutamate. Sulbutiamine is categorized under Dopaminergics. It is also known as Arcalion, Enerion, Bisibuthiamine, Youvitan.
Also Known Arcalion, Enerion, Bisibuthiamine, Youvitan
Description Commonly sold under the brand name "Arcalion" is derived from two Thiamine (Vitamin B1) molecules synthetically bonded together helping it effectively cross the blood-brain barrier. This supplement is important for proper energy metabolism and improved nerve transmissions within the body's nervous system. It also has been thought to improve conditions such as chronic fatigue. Nootropic wise, it increases both memory and alertness by acting on dopamine and glutamate.
Typical Dose 400mg

Benefits and Effectiveness

What is Sulbutiamine?

Sulbutiamine's Role On Cognition

Being a synthetic derivative of thiamine or Vitamin B1, it was first used to aid in the treatment of Berberi and Asthenia. Currently it has been widely used for a variety of conditions including somatic and psychic inhibition, psychological stress, and even viral and bacterial post infection. It has also been a popular drug among athletes and health enthusiasts since it has properties known to combat fatigue while being a non-prescription drug. This effect is mainly because it possesses mild stimulatory effect without the negative effects of amphetamines. This mechanism is attributed to Sulbutiamine acting only upon dopamine and not with other catecholamines. As with cognitive function, there is an increase in glutamate and acetylcholine activity, leading to improved memory. Patients with Parkinson's and schizophrenia may greatly benefit from using this drug which would also elevate mood. (5)

Understanding Sulbutiamine Effects

Sulbutiamine is used today as a cognitive enhancer as well as for therapeutically for certain conditions listed below.

1. Sulbutiamine and its role on Memory
The drug improves memory through the potentiation of cholinergic and glutaminergic transmission. Because of this, it has been used as a treatment for patients suffering with early-stage and moderate Alzheimer's disease alongside an acetylcholinesterase inhibitor to improve the performance of their daily activities. Aside from its use for Alzheimer's disease, Sulbutiamine also has a positive impact on patients suffering from schizophrenia by improving their memory. (1)

2. Effects on erectile dysfunction (ED)
A study was conducted on 20 patients suffering from psychogenic erectile dysfunction. They received Sulbutiamine treatment and the results showed that 16 patients had an improvement in their erectile function at the end of the study. (1)

3. Sulbutiamine and Dopamine
It has been found that it also acts on the Dopaminergic system. Dopamine is the neurotransmitter responsible for a individual's mood particularly in reducing anxiety. Through the stimulation of Dopamine levels in the brain brought about by Sulbutiamine, the user may expect an enhanced mood thus, also influencing a cascade of events such as an improvement in the ability to focus as well as a reduction in stress and anxiety levels and an improvement in the ability to respond to stress. Because of this, the individual may think and perform better thus, leading to increased productivity. (5)

Research field

Many clinical studies have already been conducted with Sulbutiamine with the aim of discovering and knowing more about the potential uses for this drug. Below are the results of some studies:

1. Effects of Sulbutiamine on Diabetic Polyneuropathy: An Open Randomized Controlled Study in Type 2 Diabetics
This study involved 30 patients suffering from diabetic polyneuropathy and were divided and randomly assigned into two groups- first group of 15 patients received only a placebo treatment while the second group, still composed of 15 patients, received the Sulbutiamine treatment. At the end of the study, it has been shown that Sulbutiamine can improve peripheral nerve function in patients with diabetic polyneuropathy. There was an improvement in neurological signs and symptoms with the group who received Sulbutiamine treatment as compared to the controlled group who only received placebo treatment. (3)

2. Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimers disease
This study involved patients suffering from early stage to moderate Alzheimer's disease and were assigned into two groups- one group received only placebo treatment while the other group received the actual Sulbutiamine treatment. The results of the study have shown that the drug demonstrated to be a potential treatment for Alzheimer's disease. This is because Sulbutiamine potentiates that of the glutaminergic and cholinergic transmissions of the Prefrontal Cortex and Hippocampus, thus influencing cognition and mood. (5)

Sulbutiamine vs. Caffeine
For most people, caffeine has already been part of their daily routine. Some people can't even start up their day in a lively manner without sipping a cup of good coffee. But why is there a comparison between caffeine and Sulbutiamine? Well, both of them act as stimulants and provide the energy needed for the day's work. However, Sulbutiamine has its edge over caffeine mainly because it does not produce the side effects that caffeine may bring such as jitters, anxiety and restlessness. With this, a growing number of people have now turned to Sulbutiamine being a better option. (4)

How do I use Sulbutiamine?

1. Proper Sulbutiamine dose and frequency
It is imperative to get the dose right to get the desired effect, while eliminating or minimizing side effects. The recommended Sulbutiamine dosage is between 400 mg to 1000 mg within a 24-hour timeframe. You might want to take it once daily or take multiple doses each day. Note that it would be best to start with the lowest dose possible that still yields the desired effects. It would also be best to consult your doctor or healthcare provider first before starting any medication since an individual's condition and health may play a factor in it's efficacy. (2)

2. Stacking Sulbutiamine
Mainly done to maximize a drug's potential and also, in order to yield more positive effects, or to eliminate or minimize the side effects that the drugs may provide. Because Sulbutiamine acts on the cholinergic system, it would be a great idea to stack it with Cholinergics. In this way, the cholinergics may provide a quality and sustained release of Acetylcholine that may greatly aid in Sulbutiamine's action in our brain. Because of this, there will be an enhanced cognitive function and increased learning capacity. Moreover, Sulbutiamine may also be stacked with other powerful noootropics such as a Racetam. For example, Pramiracetam, a member of the Racetam family, would synergize Sulbutiamine's effects thus, yielding a more favourable and powerful outcome. Expect enhanced cognitive performance as well as greater mental clarity. However when stacking, we should have a thorough understanding of drugs since some of them may not go well with other supplements.

3. Sulbutiamine administration
Sulbutiamine is now available in several forms including tablets, capsules, and powder. Arcalion, specifically, is manufactured and supplied in 200 mg tablets. The powder form is fat-soluble so it can't be mixed with water or juice instead, taking it with fish oil or milk would be a good option. Taking Sulbutiamine with fat will ensure a better and faster absorption. However, some users find the taste of the powder form to be not that good because of its strong and foul taste. Because of this, some prefer to use the capsule or tablet form. But, either way still poses still the same effects. Moreover, it would be best not to take Sulbutiamine for an extended period of time in order to prevent building a tolerance. You may cycle on it on a weekly basis. (2)

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Where Can I Buy Sulbutiamine?

It is not exactly an over the counter drug but in the US there is no regulation to prohibit it's use, meaning as of 2016 it is not a controlled substance. Sulbutiamine tablets, capsules, and powders exist at the vendors site. We recommend the pill form for convenience. Consult a doctor before buying it here.

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Additional References:
Reviewer: Kathleen R. RN, PT
Wiki Last Updated: 2016-12-07

Sulbutiamine Dosage


Side Effects

Rare cases of mild agitation or skin rashes from high doses.

Results & Experiences

No data available

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