Pramiraceram's parent compound is Piracetam, is approximately 1000 times more potent and is regarded as one of the strongest nootropic supplements available. It is sold under the brand names Remen, Neupramir, and Pramistar. In the United States it has not been approved for any medical use although researchers have considered that it may be useful in treating memory loss among those with neurodegenerative disorders and brain injury. Its primary mechanism involves increasing acetylcholine levels in the Hippocampus- the part of the brain responsible for memory formation and retrieval, thus in turn, enhancing one's cognitive function. Moreover, the enhanced blood flow to the brain causes improved concentration and focus, and faster mental processing.
Pramiracetam is categorized under Racetams.
It is also known as CI-879, Diisoprop-yl-2-oxopyrrolidin-1-ylacetamide, CI879.
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Benefits and Effectiveness
What is Pramiracetam?
One of the primary benefits of taking this supplement is to improve 'brain power', specifically the formation and retrieval of our long term memory. Research is still on-going on this drug/supplement. In this article, we will dig deeper into it's mechanism of action and other relevant research, along with some clinical studies (on humans) that have led to this drug's popularity today.
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Understanding Pramiracetam - The Basics
Pramiracetam is said to provide countless cognitive benefits such as enhanced memory formation and recall, increased attention span, and an increase in mental energy. However, its mechanism of action is not fully understood. It is believed that after ingestion, Pramiracetam is then absorbed by the small intestines and is transported to the Hippocampal region where long-term memory formation and retrieval takes place, it then acts by increasing the uptake of Acetylcholine, an important neurotransmitter in the brain (the process is called HACU or high affinity choline uptake). Acetylcholine itself is responsible for an individual's cognitive processes including learning speed, memory, and concentration, with this mechanism, the individual may experience improved memory input/output and a higher learning capacity.
Pramiracetam not only increases Acetylcholine but also serves to increase blood flow to the brain because of the increased activity in the hippocampal region. This contributes to enhanced mental alertness as well an improved general brain health. (5)
Pramiracetam Clinical Trials & Validation
Pramiracetams benefits involving cognitive function have shown that it may be an effective treatment for memory loss and cognitive problems associated with brain injury. It may also benefit individuals suffering from dementia and Alzheimer's disease. Also, it may benefit patients with ADHD due to improved attention and focus (6). We present some of the studies below and their findings:
- Placebo-controlled study of Pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia
Medically speaking, anoxia or severe hypoxia, refers to the absence or deficiency of oxygen reaching the tissues (1). In this study, the subjects are young males suffering from memory and cognitive problems that is caused by certain types of head injury and a lack of oxygen in the brain. They were divided into two groups- one group received only the placebo treatment while the other group received Pramiracetam sulphate TID treatment with a dose of 400mg. The results showed a significant improvement among those receiving the Pramiracetam Sulphate and the subjects showed an increase in performance with regards to measures of memory, especially that of delayed recall. (2)
- Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers
In this study, the researchers administered scopolamine in two groups of twelve healthy male subjects in order to induce amnesia. Scopolamine is known to be an anticholinergic medication that may decrease the secretion of fluids and is used to relieve nausea, vomiting and motion sickness. However, it may also cause confusion, agitation, dizziness, drowsiness, and among others (3). In the study, the subjects were randomly assigned into two groups, where one group received an oral treatment of Pramiracetam administered at 600mg twice a day, and the other group only received placebo treatment for 10 consecutive days. At the 11th day, the subjects were injected intramuscularly with 0.5mg of Scopolamine Hydrobromide and significantly impaired episodic memory and selective attention tests. The results demonstrated that Pramiracetam was able to partially reduce the amnesic effects brought about by Scopolamine (4).
How to Improve Pramiracetams Effectiveness
1. Pramiracetam dosage and Frequency of In-Take
It's crucial for this racetam to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With regards to Pramiracetam being a very potent nootropic, recommendations vary considerably ranging from 200mg to over 1000mg and some consider 500mg to be the perfect dose. However, most people believe that a Pramiracetam dose between 200mg to 400mg might be the best one. As for Pramiracetam frequency, the daily dose may be divided and taken into two administrations within the day. Take note that the half of this drug is about 5-6 hours. (6)
The general consensus is to start with the lowest dose mentioned above, and see if you get any results and if not gradually increasing the dose within the safe upper limits. We strongly advise consulting your care provider to make sure there are no negative interactions if you have any pre-existing conditions or are taking other drugs.
2. Stacking Pramiracetam
Stacking Pramiracetam with other Nootropics or Choline sources will maximize the effects of Pramiracetam.
You may want to consider having a good Choline source alongside Pramiracetam, choline is considered a vital component in a stack involving racetams as racetams tend to deplete choline. Some good sources of which include Alpha GPC, Centrophenoxine and Citicoline.
Aside from stacking Pramiracetam with Choline, Pramiracetam may also be taken along with the other members of the Racetam family in order to increase and synergize each of their abilities pertaining to cognitive function. Your choices might include the powerful Noopept
, Piracetam, aniracetam among others. Consider looking at these comparison charts: aniracetam vs pramiracetam
, pramiracetam vs piracetam
, pramiracetam vs noopept
, oxiracetam vs pramiracetam.
3. Take Pramiracetam with food or on a full stomach
Pramiracetam is categorized as a fat-soluble drug, so in order for it to be more readily absorbed and metabolized properly by the body, it should be taken with food or on a full stomach more specifically, with fatty acids (think fish oil, MCT oil). Not only does it aid in the solubility of Pramiracetam but it has its own health benefits (double-win!). (4)
Pramiracetam comes in various forms such as in bulk powder, capsules, or tablets. We don't advise you buy the powder form as this racetam tastes really bad. You should shell out a bit more money and get capsules. There generally is no 'tolerance' issue that you need worry about with Pramiracetam. We generally audit many online sources for the most reliable vendor, with the best rates (and if it's on sale) and then link to them as part of our recommended place to buy online. You may click here to buy Pramiracetam
from a reputable source that provides a certificate of authenticity by a 3rd party and has a history of being a reliable vendor amongst the nootropic community online.
- Erowid experience link: http://www.tandfonline.com/doi/abs/10.3109/02699059109008110
- Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers. Mauri, M., Sinforiani, E., Reverberi, F., Merlo, P., Bono, G. Archives of gerontology and geriatrics. (1994) [Pubmed]
- Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat. Corasaniti, M.T., Paoletti, A.M., Palma, E., Granato, T., Navarra, M., Nisticò, G. Funct. Neurol. (1995) [Pubmed]
Reviewer: Kathleen R. RN, PT
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Wiki Last Updated: 2016-06-07
The most notable side effect of Pramiracetam is headaches. However, it can be easily eliminated with the addition of Choline.
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