Picamilon Review

Picamilon is regarded as one of the best anxiolytics given that it is a combination of GABA and niacin and can cross the blood-brain barrier easily. It was created in the late 1960s in Russia and is utilized as a prescription drug in Russia, whileas in the United States, it is unregulated. With niacin as its precursor, Picamilon has the ability to increase energy levels, making it a very unique anxiolytic. Overall it provides a mild tranquilizing effect which helps reduces aggressiveness while being mildly stimulating which can help improve alertness and cognitive function. Picamilon is categorized under GABAergics. It is also known as nicotinoyl-GABAm Pycamilon, Pikamilon.
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Benefits and Effectiveness

What is Picamilon?

Are you anxious about an upcoming exam, presentation or a big event? Having very high levels of anxiety puts you in a more stressful situation and what's worse is that it also affects the way you think and act. If you are looking for a potent anxiolytic that serves to promote cognitive improvements and not affect your wakefulness, then Picamilon is the answer. It is great when used alone or when stacked with other potent nootropics. It is one of the best compounds to be considered for all your anxiety and stress shortfalls. Lets look at what Picamilon has to offer and its effects.

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The effects of Picamilon and its Mechanism of Action

Picamilon is essentially a combination of Niacin and GABA. Niacin is also referred to as Vitamin B3 and just like the other B complex vitamins, it is vital for the storage and production of energy. It also serves to have antioxidant properties and keeps the body healthy by preventing damage to the tissues. If there is insufficient supply of needed Niacin levels, Pellagra may result (dermatitis, diarrhea, and mental disturbance, and is often linked to over dependence on corn as a staple food.) ⁴. On the other hand, GABA, also known as Gamma Aminobutyric Acid, is the major inhibitory neurotransmitter of the central nervous system. It acts by reducing excessive excitability of neurons. It is also responsible for the regulation of the body's muscle tone (5).

When Niacin and GABA are stacked together, they provide a variety of significant improvements both mentally and physically. Lets now look at what Picamilon has to offer given the capability of Niacin and GABA.

1. Picamilon for Enhanced Cognitive Function (Nootropic Properties)

Picamilons cognitive benefits are greatly attributed to its influence on increasing blood flow to brain. How is blood flow associated with improved cognitive function? Blood carries oxygen and several nutrients needed by our brain cells to function efficiently. Therefore, patients with cerebral vascular impairments would benefit greatly by using Picamilon as it makes for a efficient Cerebral vasodilator. The patients I am referring to could have organic brain syndromes from trauma, cerebral atherosclerosis or toxic brain lesions based on trial findings.
With this mechanism, Picamilon may enhance a person's cognitive functions specifically that of formation, storage and retrieval of memory, increased learning ability, and improved focus and attention span in healthy humans. Moreover, oxygen carries glucose which is the fuel for our cells. With this, it will aid in the metabolism of energy and will provide a significant boost in one's mental energy. As a result, our brain cells will have improved endurance to perform mental tasks. (1)

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2. Picamilon for Managing Stress and Anxiety

Picamilon's anxiolytic effects may be attributed to its ability to boost GABA levels in the brain. Because GABA cannot cross the blood brain barrier alone, Picamilon helps GABA do so. Moreover, it also stimulates an increase of GABA levels in the brain and since GABA is an inhibitory neurotransmitter, it serves as a powerful anxiolytic compound. It promotes a reduction in anxiety levels thus positively affecting stress levels and how one responds to stressful situations. GABA helps users achieve an overall relaxed state of mind.

Because of this mechanism, Picamilon may improve one's mood and may be beneficial for individuals experiencing depression. Although Picamilon serves as an anxiolytic, it does not seem to affect one's wakefulness levels even though it can be a mild stimulant. (1)

3. Picamilon for a Brain Health

It has been found that Picamilon serves to promote a healthy brain. This is because it has a detoxifying effect on neurons. In this way, toxins and harmful compounds are removed from the brain with Picamilon. The neurons may function more efficiently and effectively along with the rest of your body once these toxins are removed. Keep in mind that Picamilon is a compound that needs to be cycled and should not be taken like a vitamin on a daily basis. (2)

How do I maximize the effects of Picamilon?

It is crucial for you to take the right amount and take it at the right frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. Daily Picamilon dosages may vary between 50 mg to 300 mg. If you wanted to improve your mood or have boosting effects, the suggested Picamilon dose would be between 5mg to 100mg daily. On the other hand, if you seek anxiolytic effects and stress relief, the recommended dosage would be 100 mg to 200 mg daily (2). These suggested doses may be divided and taken into multiple administrations within the day to have a more constant and sustained release of effects. Picamilon acts quickly and tends to have noticeable effects for up to 4 to 6 hours. (3)

Picamilon comes in both capsule and powder form. The capsules come in doses of 150 mg so if you wanted to have a variation of doses, the powder form would be a better option. However if you want an easier administration, you may opt in taking Picamilon capsules. Since Picamilon is water-soluble, it would be best to take it with an empty stomach for faster absorption. (1) When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increase it over time -- if needed. You might also want to consider consulting your doctor or healthcare provider first since your condition and health status may play a role.

2. Stacking Picamilon with other Nootropics

Stacking is done for the purpose of maximizing a drug's potential and also, in order to yield more positive effects, to synergize other drugs/supplements, or to eliminate or minimize the side effects that the drugs may provide. Picamilon stacked with a Racetam would be a great option. This way, these two drugs will work together and potentiate each other's effects in delivering enhanced cognition. There would be a drastic increase in one's learning ability as well as an increase in processing speed. An example of which will Picamilon and Pramiracetam stack. The racetams are generally (especially Piracetam for example mild and with decades of research).

On the other hand, Picamilon may stacked with a anxiolytic supplement such as L-Theanine may work well in reducing anxiety as well. In comparison to Phenibut (another anxiolytic drug/supplement), Phenibut appears to have sedative effects while Picamilon does not affect wakefulness. Having a thorough understanding of the drugs in a stack is important because some drugs might not go well with the others. Stacking supplements depends on your needs and personal preferences however, it would be best to consult your doctor or healthcare provider first.

Where can I buy Picamilon?

You may purchase Picamilon through online sources or through a pharmacy if you happen to live in Eastern Europe or Russia. Picamilon comes in capsule or powder form, powder form being cheaper and easier for you get the exact dosage for. It is recommend that you buy through our TRUSTED and SAFE vendor always by clicking here, we change vendors from time to time so there isn't one vendor we can just name, it changes based on recent quality tests (COA), price and other factors.

References:
(1) Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome
(2) Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data
(3) Psychiatric Care of the Medical Patient
(4) Niacin
(5) Gamma Aminobutyric Acid

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Picamilon Dosage

50 to 300 mg/day

Side Effects

Side effects reported are generally mild which includes lightheadedness, headache, nausea, irritability, low blood pressure, and flushing of the skin. Although Picamilon is safe to use on a daily basis, it would be best to cycle it in order to avoid tolerance and to ensure that results will still be achieved. You may want to substitute its use for a short period of time with other anxiolytic drugs such as L-Theanine or Phenibut.

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