PRL-8-53 was patented by the late Dr. Nikolaus Hansl, a neuropharmacologist of Creighton University in Nebraska in the year 1975. PRL-8-53 is significantly nootropic and does not cause harm. Animal test studies show that PRL-8-53 has the ability to enhance learning in mice without any negative effects. In a human study conducted last 1978, a single dose of PRL-8-53 was found to improve word retention by greater than 200 percent.
Right after Dr. Nikolaus Hansl patented PRL-8-53, he funded a human study that greatly supports the drug’s benefits as a nootropic. The study has 30 physically fit individuals between the ages 24 and 86 years. The retention capacity of each individual in the study was measured. The results show that those individuals having initially low scores or who were over 30 years of age showed significant improvement after taking a 5 mg dose of PRL-8-53. However, those participants that had high baseline retention scores demonstrated little improvement after taking PRL-8-53. No adverse effects reported in the study.
Durk Pearson furtherly increases the people’s interest in PRL-8-53 by saying that PRL-8-53 functions well in enhancing a person’s memory. Normally, a person can recall at least 7 to 8 digits by looking at them for one second. However, PRL-8-53 amazingly provides an average individual a memory span of 21 to 22 digits.
Despite of all the positive effects that PRL-8-53 bring, and all the evidences that support the nootropic capability and safety of this drug, the testing is limited and this drug is still considered experimental.
The exact mechanism of action of PRL-8-53 is not fully understood, however, it was believed that it could regulate the brain’s response and production of numerous neurotransmitters. Dr. Hansl’s reports on both animal and human studies indicated that PRL-8-53 has the ability to potentiate dopamine, improves the brain’s response to acetylcholine, and partially inhibits the secretion of serotonin. Despite that Dr. Hansl reported those actions in his human study in 1978, it does not precisely describe the mechanism of action.
PRL-8-53 supports the concept that dopamine modulation has an important function in its effects since numerous elderly individuals experienced the most nootropic benefits after administering PRL-8-53. In an article entitled “Learning & Memory Improvement Through Chemistry: Dream or Reality in the Offing?” that was published in the year 1979, Dr. Nikolaus Hansl stated that PRL-8-53 has the ability to augment responses to noradrenaline both centrally and peripherally in animal models. Thus, it is justifiable to assume that PRL-8-53 could likewise provide the similar effect on humans. Additionally, PRL-8-53 is capable of converting short-term memory to long-term, leading to an increased storage of information.
In the same article, Nikolaus Hansl stated that PRL-8-53 is not considered as a stimulant. In the animal study, PRL-8-53 toxicity appears after a huge amount of dose that is a thousand times higher as the human dose was given. In conclusion, we now have a drug that is potentially useful that can boost a chemical system in the brain, which is the cholinergic system, that leads to improvement in our ability to retrieve information, and enhance our ability to recall.
Given the benefits of PRL-8-53, some researches decided to take a closer look on it and discover its additional benefits. In one human study, each test subject was given a certain dose of PRL-8-53 and a placebo at different times. Each of them were asked to memorize 12 syllables. Amazing results were found. Those participants who took PRL-8-53, even those who have poor short-term memory, got high scores. On the other hand, participants in the placebo group reported to have minimal improvements in their memory tests. Conversion of short term memory into long-term improved by a reasonable margin. Those participants who have low initial scores show greater improvement that those who have initially higher scores.
The test participants were asked to recite the memorized words after a 24-hour period and a 96-hour period. Individuals who have good short-term memory did not experience significant improvement after taking PRL-8-53. However, those individuals who have poor short term memory showed mark improvement in their test scores.
So what does this imply to you? In conclusion to this study, those individual who have poor short term memory gain the most benefits after taking PRL-8-53. Not only will they be able to retain information for brief periods of time, but their long term memory will have significant improvements as well. PRL-8-53 can also provide some benefits for those individuals who have good short term memory, however, these benefits are isolated in further enhancing their short term memory and not their memory formation.
According to the human study, there were no side effects observed when taking a dose of 5 mg of PRL-8-53. Animal studies show that PRL-8-53 has significant therapeutic threshold, however, since no toxicity studies have been conducted, there are no enough evidence to prove this claim.
Since very few studies have been conducted with regards to the effects and effectiveness of PRL-8-53, it is strongly advisable to consult a drug specialist before taking this type of drug. However, as mentioned above, individuals were give a dose of 5 mg. The patent information available for the recommended dose of PRL-8-53 ranges from 0.01 to 4 mg/kg of bodyweight. However, since this range is quite high, the ideal range is between 0.05 and 1.2 mg/kg of bodyweight. This means that a dosage between 3.4 and 81.6 mg should be taken by an individual that has a bodyweight of 150 pounds. On the other hand, experiments in rats and mice that were given a high dose of PRL-8-53 showed reduction in motor activity.
The effects of PRL-8-53 sets in quickly but gradually wears off within a period of 90 minutes or so. As such, many users chose to administer a dose of 5 mg, taken 2 to 3 times a day. So far, as for humans, there have been no reports about the negative impacts of PRL-8-53 when taken at higher doses. However, before deciding to do the same, it is highly suggested that you consult your doctor or a drug specialist first.References:
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