Huperzine A, also called selagine, is an alkaloid compound commonly used to treat Alzheimer's disease and other neurodegenerative diseases. It is known for its ability to improve memory and cognitive abilities by increasing acetylcholine levels in the brain and by blocking the action of cholinesterase. This is particularly effective when studying or trying to learn any new material. Also, it acts as an antagonist of the NMDA receptor and has neuroprotective properties by protecting neurons from damage due to glutamate, peroxides, and beta-amyloids. However, it cannot be medically endorsed as a treatment until additional research is conducted.
Huperzine A is categorized under Acetylcholinesterase Inhibitors.
It is also known as 1R, 9S, 13E-1-amino-13-ethylidene-11-methyl-6-azatricyclo- [126.96.36.199 2, 7 ]trideca-27, 3, 10-trien-5-on, Qian Ceng Ta Huperzia Serrata.
Also Known 1R, 9S, 13E-1-amino-13-ethylidene-11-methyl-6-azatricyclo- [188.8.131.52 2, 7 ]trideca-27, 3, 10-trien-5-on, Qian Ceng Ta Huperzia Serrata
DescriptionHuperzine A, also called selagine, is an alkaloid compound commonly used to treat Alzheimer's disease and other neurodegenerative diseases. It is known for its ability to improve memory and cognitive abilities by increasing acetylcholine levels in the brain and by blocking the action of cholinesterase. This is particularly effective when studying or trying to learn any new material. Also, it acts as an antagonist of the NMDA receptor and has neuroprotective properties by protecting neurons from damage due to glutamate, peroxides, and beta-amyloids. However, it cannot be medically endorsed as a treatment until additional research is conducted.
Looking for a excellent study aid that provides long-lasting effects? Not only is this a natural nootropic compound but it also promotes a healthy brain and improved neuronal communication. Huperzine A, a natural supplement derived from club moss, is one of the most potent nootropics of ALL time. It is known not only for the cognitive enhancement properties it provides and is one of the most well-studied supplements due to promising treatment results for cognitive issues, specifically Alzheimer's disease and dementia.
What are the benefits of Huperzine A and How does it work?
Huperzine A works in a similar way to Racetams, it serves to influence the Cholinergic system and increases the level of Acetylcholine in the brain. Choline is a important neurotransmitter that is strongly associated with better memory and cognitive functioning. However, the difference lies in that Huperzine A acts as an Acetylcholinesterase inhibitor. Meaning, it stops or inhibits the action of Acetylcholinesterase, the enzyme responsible breaking down Acetylcholine in the brain. Because of this, it indirectly increases the levels of the neurotransmitter. In contrast, Racetams do not act as an inhibitor to the enzyme instead, they directly increases Acetylcholine levels in the brain.
Because of this mechanism, the user would experience general enhanced cognitive function specifically that of memory formation and retrieval and consolidation. Moreover, Huperzine A would be of great benefit for individuals suffering from age-related cognitive decline such as: dementia or Alzheimer's disease. This benefit may be attributed with Huperzine A acting on NGF or Nerve Growth Factor. This nootropic increases the levels of said compound which is believed to help in the formation of new nerve cells. (2)
In relation to Huperzine A and Alzheimer's disease, several studies have been conducted and demonstrated promising results. Patients who received Huperzine A treatment showed improvement in their memory and ability to think. In individuals with no cognitive decline, Huperzine A improved memory formation and retention. (1) Also, Huperzine A appears to be neuroprotective as it has demonstrated to protect the brain from toxins and damaging compounds. Because of this, it promotes a healthy brain and proper brain functioning. (3)
1. Proper Huperzine A dosage, mode of administration and frequency It's crucial for this supplement to be taken at the right time and frequency for it to produce the desired effects. Huperzine A may be administered in two ways- either orally or intravenously. The use of the intravenous Huperzine A method is done for individuals with muscle weakness and the appropriate dosage and administration is given by the authorized healthcare professional. On the other hand, oral Huperzine A is generally recommended between doses 50 to 200 mcg and is taken twice a day. This natural nootropic requires a much lesser dosage compared to other drugs because it is highly potent and powerful. For the treatment of Alzheimer's disease, a dose of up to 400 mcg may be taken (2). Moreover for the geriatric population, the recommended dosage would be 30 mcg and taken twice daily. (1)
To avoid physical habituation, experts recommend that Huperzine A be taken in cycles such as taking it for 3 weeks then cycling it off for about a week. It can be taken alone without the presence of food and can still be easily absorbed in the gut. However, we should take note that it would be best to start with the lowest possible dose yielding the desired effects. Also, it is imperative for you to see and observe how you personally react, especially if you are a first-timer. Moreover, some people may also need to consult their healthcare provider first for their suggested Huperzine A dosage and frequency since their condition and health status may play a role when taking some medications.
2. Stacking Huperzine A with other Nootropics for Better Results Done for the purpose of maximizing a drug's potential and also, in order to yield more positive effects, to synergize each other, or to eliminate or minimize the side effects that the drugs may provide. A popular and powerful stack today would be the Huperzine A and Noopept stack. Both nootropics are known to be potent and shows higher bioavailability compared to other drugs. They synergize the effects of each other and as a result, the stack will do wonders with regards to one's cognitive performance. Moreover, since Noopept's effects may be experienced 15 minutes following its ingestion, the stack would provide a significant kick off to your brain's function. On the other hand due to Huperzine A's long half-life of approximately 10 to 14 hours, there would be a sustained release of positive effects needed for the long hours of your cognitive performance (3). With the Huperzine A - Noopept stack, this will be of great help as a study aid as well as for individuals who want a step up in their learning abilities.
Another stack that would be of great benefit is the Huperzine A and Choline stack. Since Huperzine A is an acetylcholinesterase inhibitor, the supplementation of a quality source of Choline can further increase Acetylcholine levels and as a result, may greatly potentiate the action of the former and yield greater cognitive results. Some quality sources of choline include Alpha GPC, Centrophenoxine, Citicoline and among many others.
Where to buy Huperzine A
It is available over the counter, you do not need any prescription from your doctor in order to purchase. You should consider purchasing a quality Huperzine-A supplement rather than the cheapest as chances are it will not be as potent or bioavailable as you would want it to be to see results. Consider purchasing Huperzine-A through this link here and see our top choices. We generally you buy or stick to these brands as they can contain more of the bioavailable version your body can actually use and has the rightly advertised dosage: AOR, Swansons and Life Extension, all of which can be found using our link above. It is readily available in powder or tablet form, the tablets seem to be more convenient and come in 100 mcg and 200 mcg doses while the Huperzine A powder is cheaper and can be bought in bulk. Consider Huperzine A to quickly notice a significant step up in your cognitive function.
Reviewer: Kathleen R. RN, PT Wiki Last Updated: 2016-02-14
Huperzine A appears to be safe even with daily use. However, occasional symptoms include digestive upset, nausea, vomiting, and diarrhea. Also, if taken in excessively large dosage, it can cause slurred speech, muscle twitching, drooling, incontinence, elevated blood pressure, and a slow heart rate. When these effects are experienced, stop Huperzine A use and consult your doctor and healthcare provider for proper advice.