Galantamine is an alkaloid that is obtained synthetically or derived from the plant Galanthus caucasicus and has been used as a form of medicine since the 1950's. This is a substance that is primarily used to treat mild to moderate dementia related to Alzheimer's disease and other various memory impairments that are of vascular in origin. Although it does not directly cure Alzheimer's disease, but it does its benefit by improving memory, awareness, and the ability to perform daily functions. This effect is then attributed to Galatamine being a centrally-acting acetylcholinesterase inhibitor, elevating acetylcholine in the cerebral cortex. Galantamine slows the breakdown of acetylcholine, so it can build up and have greater effect. Some research suggests that this substance improves memory functions in adults with brain damage. Other uses of this drug includes: supplement for lucid dreaming, used as a sleep aid and nootopic, and as an augmentative therapy in children with autism.
Galantamine is categorized under Acetylcholinesterase Inhibitors.
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Benefits and Effectiveness
What is Galantamine?
Galantamine, the Powerful Nootropic and Sleeping Aid
When you have been through a bad day, your quality and ability to fall asleep is affected, right? Moreover, the way you think and act is also being affected when you are under stressful situations or did not have enough rest. In this way, it impairs your overall productivity levels leaving you more frustrated. Now with Galantamine, it will cater to each of your dilemmas- whether be it cognitively, with regards to your quality of sleep, to how you deal with stressful situations. Galantamine serves to have several benefits that may be of great help- may it be to the students, professionals, or to individuals who wanted to have a step up in their cognitive function. Used to treat some motor dysfunctions, Galantamine is now being used for cognitive purposes.
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What are the effects of Galantamine and its mechanism of action?
Basically, Galantamine works in two quite common mechanisms of the nootropic drugs. This involves the following:1. Galantamine and the inhibition of Acetylcholinesterase
The first method in which Galantamine works is through the inhibition of the activity of Acetylcholinesterase. Acetylcholinesterase is an enzyme that breaks down the important neurotransmitter Acetylcholine that is greatly associated with cognition. With Galantamine blocking the breakdown of Acetylcholine, there will be an indirect increase of Acetylcholine levels. (1)2. Galantamine and the acetylcholine receptor sites
Secondly, Galantamine works just like the other nootropics, most especially that of the Racetams. It acts by directly influencing the receptor sites of Acetylcholine. Because of this stimulation, the sites are now being more receptive to Acetylcholine. As a result, it increases the efficiency of Acetylcholine and there will also be an increase in the levels of the neurotransmitter. (2)
The two mechanisms in which Galantamine increase the Acetylcholine levels greatly results in an enhanced cognitive function. There will be an improvement in memory formation and recall as well as an improved concentration and increased attention span. Because of this, it will be of great benefit to students who want to have a significant step up in their cognitive function. 3. Galantamine for energy
Aside from its influence on Acetylcholine levels, Galantamine has also been shown to affect two other neurotransmitters namely adrenaline and noradrenaline. Both of these neurotransmitters are secreted by the adrenal medulla and serves to have its purpose with regards to our energy and how our body responds to stress (3). Because of Galantamine’s influence on the said neurotransmitters, the individual will have an improved ability to respond with stressful situations as well as the needed energy by the brain and body to do both mental and physical tasks. (1)
4. Galantamine for sleep
It has also been shown that Galantamine enhances one’s quality of sleep. Galantamine reviews claim that users have an improvement in their sleep as well as their sleeping patterns. Some have experienced an easier ability to fall asleep while some reported being feeling relaxed and well-rested the following day. Because of this, Galantamine may help those individuals suffering from insomnia and other individuals who have sleeping problems. (1)
On the other hand, Galantamine is used by some people to achieve lucid dreaming or out-of-body-experiences. This can be achieved with a Galantamine dose of between 4 mg to 8 mg taken after five hours and practicing meditation. 5. Galantamine in the medical field
Because of Galantamine’s influence on cognition, it serves to have its benefit now in the medical setting. At the present, Galantamine has been approved by the FDA as a treatment for Alzheimer’s disease. It might also be a potential treatment for ADHD and different forms of dementia. (2)
How do I maximize the effects of Galantamine? 1. Proper Galantamine dosage and frequency
It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Galantamine, how much of it do we really need each day? Basically, a very small dose of Galantamine is needed to achieve optimal results. This is because it is very potent that an individual only needs a small Galantamine dose of between 4 mg to 12 mg. For its frequency, it may be taken 2 times daily but the total daily dose should not exceed 24 mg. (1)
It would also be best to space out your Galantamine intake since it has a relatively long half life and can stay in your system for 48 hours. In this way, you may also prevent building resistance to Galantamine and ensure that results are still being achieved.
When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role. 2. Stacking Galantamine
Stacking has been a popular practice nowadays. This is done for the purpose of maximizing a drug’s potential and also, in order to yield more positive effects, to synergize each other, or to eliminate or minimize the side effects that the drugs may provide. With the case of Galantamine, what drugs and supplements are best to use in conjunction to it? Working just like the Racetams, Galantamine may be stacked with any member of the Racetam family. An example of which may include the Galantamine and Pramiracetam stack. Both nootropics work by increasing the levels of Acetylcholine. With this combination, they will synergize and potentiate each other’s effects leading to a more powerful stack.
Because Galantamine stimulates the Acetylcholine receptor sites, it may be stacked with Cholinergic drugs. In this way, the cholinergics will provide a constant and sustained quality supply of Acetylcholine needed for a more efficient functioning. An example of which may be the Galantamine and Alpha GPC stack. With this, there will be a more enhanced cognitive function. Other Cholinergics that may also be used include Centrophenoxine, Citicoline and among many others.
Aside from the natural nootropics, you may also want to stack Galantamine with other very potent nootropics to achieve faster and more powerful cognitive benefits. Examples of which may include Noopept, Adrafinil, Pramiracetam, and among many others.
However, we should take note that Galantamine should not be stacked with other stimulants and cholinesterase inhibitors such as Huperzine A.
Having a thorough understanding of the drugs you wanted to have in a stack is important because some drugs might not go well with the others. Stacking supplements greatly depends on your needs and personal preferences however, it would be best to consult your doctor or healthcare provider first.
Galantamine Safety and Side Effects
Galantamine has been regarded as a safe and highly tolerated drug. However, there have been some reported mild Galantamine side effects which includes headaches, dizziness, nausea, fatigue, and loss of appetite. Moreover, allergic reactions may develop and in this case, it would be best to seek proper medical assistance immediately. (2)
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(1) Kavanagh S, Van Baelen B, SchÃ¤uble B. Long-term effects of galantamine on cognitive function in Alzheimer’s disease: a large-scale international retrospective study. J Alzheimers Dis. 2011
(3) Endocrine Web
Reviewer: Kathleen R. RN, PT
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Wiki Last Updated: 2016-06-08
The most notable symptom of Galantamine usage would be Gastrointestinal symptoms.
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