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Fladrafinil (CRL-40,941) Review

Fladrafinil (CRL-40,941) Review Fladrafinil falls within the eugeroic classification of drugs, thus promoting wakefulness. It is very similar to the substance adrafinil, except that a ring of the chemical has been altered. Despite their simiilarities, further researches must be conducted in humans to verify any hypothesized nootropic effects. Among animals, this medication has been noted to reduce aggression. Fladrafinil (CRL-40,941) is categorized under Eugeroics.
Fladrafinil (CRL-40,941)
Also Known
Description Fladrafinil falls within the eugeroic classification of drugs, thus promoting wakefulness. It is very similar to the substance adrafinil, except that a ring of the chemical has been altered. Despite their simiilarities, further researches must be conducted in humans to verify any hypothesized nootropic effects. Among animals, this medication has been noted to reduce aggression.
Typical Dose 250mg

Benefits and Effectiveness

What is Fladrafinil (CRL-40,941)?

Fladrafinil has been spotted in the nootropic drug markets and has also been used in the research chemical markets as of late 2013. There are two different types of metabolites that come from Fladrafinil; the two types are Flodafinil and Flodafinilic acid.

Nootropics have been called by others as smart drugs. This is because the drug works on the brain specifically. It can also go by the term, that has been called by many, as the brain, intelligence and memory drug. Fladrafinil is one of the drugs that belong to the nootropic group.

It is interesting to note that Fladrafinil is a promoting agent drug for alertness that was created in 1970’s. This drug can also be referred to as CRL-40,941 or better known as fluorafinil. It is the bis(p-fluoro) ring-substituted derivative of adrafinil and is also known to be an alternative to adrafinil and modafinil, but stronger in effect.

How it works?

Fladrafinil promoting agent for wakefulness. It is shown to modulate Glutamate receptors positively which is theorized to be the lead mechanism of action behind the benefits of the cognition of this smart drug. It is has shown that it is more effective than modafinil and adrafinil and has proven that it has more effectivity, than both modafil and adranifil molecules combined, in their indications. It also shows fewer side effects, which is great because it happens to be a molecule that is similar to both modafinil and adrafinil, and has a much greater positive effect as compared to the two. Fladrafinil used for treatment of disorders such as shift work sleep disorder, obstructive sleep apnea which in results in excessive daytime sleepiness, and narcolepsy.

Fladrafinil has the ability to possibly treat ADHD as well as idiopathic hypersomnia, but with low toxicity. Research still has to be done in order to prove this claim. On the contrary, Fladafinil has been shown to significantly enhance cognition as well as the improvement of the student’s memory.

It has been found recently that Fladrafinil can provide better results than those achieved with current treatments based on psychostimulants. It would be able to treat symptoms that were once resistant to current treatments, with no symptom rebound effect and would have a decreased risk to poisoning of the drug.

Buy Fladrafinil (CRL-40,941)


There are many different reasons as to why the smart drug is very useful. To start off, many users have confirmed that by using this smart drug there has been a significant improvement in their concentration. Since it removes fatigue among its users, they now tend to be always very proactive. People suffering from any kind of excessive aggression choose to use this drug because it helps lower aggression. It is also good for those that have a hyperactivity problem because it has a calming effect, which many users tend to prefer the drug above those in the same category because of its potency. There was a research that was done that proved that the drug promotes wakefulness. It has also shown that the drug is even two times stronger than adrafinil. So if you have been using adrafinil and seems to not be effective, it is very easy to switch over to fladrafinil.

Fladrafinil has been indicated as a possible treatment for conditions such as Alzheimer’s, ADHD, insomnia and depression because of its potential benefits that improve memory and cognitive function, more alert consciousness in general, and as a result, greater motivation.


Psychedelics in different parts of the world have done research about Fladrafinil. It has been recommended that Fladrafinil be used in the treatment of problems like insomnia, in early research. Prolintane is less addictive, unlike other nootropic out there in the market. It is a strong but safe medication for users. It is a legal stimulant and can be recommended for use by athletes and body builders it does not have levels of toxicity. The stimulant had ingredients or substances that researchers have proven it to have a direct link in replenishing brain sensors. Since ingredients such as prolintane are safe stimulants, it is best to note that there was no brain damage reported on its users.


Other nootropic drugs were originally invented in the late 1970's which was a part of a research carried out by the French Laboratoire L. Lafon, which was also led by Dr. Michel Jouvet. Fladrafinil was actually discovered in 1970 and was found to have anti-aggressive properties on rats as well as people. They later discovered that it was 2 times more powerful than adrafinil.


Fladrafinil has a few positive feedbacks from users who are currently taking it. It improves on patient’s wakefulness, therefore showing an improvement in their concentration. It has been said to help increase energy levels of body builders which makes them work harder and eliminates pain limits during their workouts. Even though there were good positive feedbacks that were given, there have also been complain (or negative reviews) which included anxiety and increased blood pressure. No matter positive or negative effects of Fladrafinil, it is always good to note that the use of it is clearly dependent on the size of dose taken by the patient.


With 200 mg being the absolute maximum that should be taken in a 24-hour period, the most common dosage is normally around 30 to 100 mg per day. The most common symptoms are similar to modafinil and other nootropic stimulants, although negative side effects from CRL-40941 at normal dosages are relatively rare. The side effects that may be included are stomach discomfort, overstimulation, headache, aggression, confusion, and vasoconstriction.

Is Faldrafinil legal?

Although the FDA does not regulate the drug, Fladrafinil, however, is legal to possess in the United States. You can purchase it easiy and have it sent by mail order.

Side Effects of Fladrafinil:

There have been some complains of feelings of nervousness. Increased risk for damage to liver has also been reported as well as an increase in heart rate, but this is usually not too much of an inconvenience to the patient and is tolerable.

Long Term Use of Fladrafinil:

After a period of two or so months, there is notable long term positive effects that has been seen in Fladrafinil. This stimulant is intended to make a customer more productive. There is reduction in aggression that have been reported, mainly due to the anti-aggressive ingredients in found in Fladrafinil. Wakefulness and increased are other long term positive effects of using the stimulant. There is one unpalatable long term effect of using Fladrafinil, which is vasoconstriction. A good amount of patients has deemed it effective as compared to other nootropics out there, which are less powerful, and have recommended its use for a long time.

Short Term Use of Fladrafinil:

Short term promotes a decrease in ‘‘mental fog’’ which therefore allows more concentration and focus to take place. It is great for those individuals who have narcolepsy and sleep apnea, which allows people to less groggy and feel more awake throughout the day so in general, a person feeling less tired. Despite having many positive effects, on the other hand, others have reported that the short-term use of Fladrafinil could cause blood pressure to increase in individuals.

How much does this drug cost?

The price of Fladrafinil ranges widely and is dependent on how much is ordered at a time, like many other research chemicals. Wholesale purchases tends to yield the cheapest prices per gram as compared to that of retail purchases. Retail amounts, which are smaller, average about 15 to 30 dollars per gram of the crystalline powder. On the other hand, wholesale prices can range anywhere from 3 to 10 dollars per gram, which usually contain 500 grams or more.

Final Thoughts

Even if some have reported that they have observed some positive effects, the general feedback on the drug was that it has unwelcome side effects such as vasoconstriction and has limited impact. It may be best to stick with adrafinil, since it is a less powerful nootropic but even if this drug may only be half as potent, on the other hand, it is much more well-known and has much fewer side effects as compared to adrafinil. In conclusion, there is no doubt that fladrafinil is effective, but until there will be more researches conducted and evidences to prove the effectivity of Fladrafinil, it is advisable to stay away from it.


Reviewer: Kathleen R. RN, PT
Wiki Last Updated: 2016-02-14

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