Citicoline (CDP-Choline) Review
Citicoline, also known as CDP Choline, Cytidine diphosphate-choline, is a popular nootropic known to improve cognitive function and brain health. It mainly increases the levels of Acetylcholine in the brain thus, improving memory and communication between neurons. Also, it is thought to increase the density of dopamine receptors in the brain. Researches also suggest that Citicoline has been used to treat stroke, head trauma, and a number of cognitive disorders like dementia and age related cognitive decline. Some have gone as far as to suggest it may be helpful in treating symptoms of ADHD. It is available as a supplement in most established countries and is believed to have significant neuroprotective properties.
Citicoline (CDP-Choline) is categorized under Cholinergics.
It is also known as Citicholine, Cytidine Diphosphocholine.
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Benefits and Effectiveness
- Attention - Increased 
- Blood Pressure - Decrease 
- Cognition - Increased 
- Memory - Increased 
- Cocaine Addiction - Decrease 
What is Citicoline (CDP-Choline)?
Citicoline, A Quality Choline Supplement
Are you looking for a quality Choline supplement that is very effective when used alone? Or are you looking for an added Choline supply for your stack? Citicoline, although not considered to be a pure cholinergic, serves to act on certain neurotransmitters to deliver its effects. When used alone, benefits are easily experienced and so much more when used in conjunction with other potent nootropics. It serves not only in enhancing your cognitive performance but also, motivates you and enhances your mood to help you deal with stress.
Citicoline as a study aid for students and professionals would be a great option to help you accomplish your tasks. Let us now know what this Choline supplement has to offer and how it delivers its actions.
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Citicoline’s effects and its mechanism of action
1. Citicoline and Acetylcholine
One of the major mechanism of action of Citicoline is greatly associated with Acetylcholine, a neurotransmitter important for proper brain functioning. Once absorbed by the body, Citicoline splits into choline and cytidine. Choline then, directly influences an increase of Acetylcholine levels thereby producing an enhanced cognitive function, memory formation and retrieval, consolidation, improved focus and sensory perceptions. It also serves to maintain and enhance the communication between the nerve cells in our brain. On the other hand, cytidine is converted into uridine which is also associated with enhanced cognitive function. (2)
2. Citicoline and enhanced mood and energy
Aside from influencing the cholinergic system, Citicoline also appears to influence other vital neurotransmitters in the brain specifically Dopamine and Norepinephrine. Dopamine is strongly associated with an individual’s reward system, cognition, attention, learning and mood as well (3). Because it increases Dopamine levels, the individual may experience an enhanced cognitive function as well as an improved mood. Citicoline may help the individual respond to stress efficiently. On the other hand, Noradrenaline levels are also raised. This neurotransmitter is associated with brain energy thus, taking Citicoline would serve to kick start your day and sustain you with the sufficient energy you need during the day (2). Moreover, Citicoline may increase the body’s overall metabolism thus, increasing oxygen supply to the brain. Because of this, there would be sufficient fuel of glucose thus increasing brain energy (5). As a result of these mechanisms that Citicoline provides, the individual may work and think more efficiently thus increasing his/ her productivity levels as well. (2)
3. Citicoline in promoting a healthy brain
Other than the benefits discussed above Citicoline works also by promoting an overall healthy brain. This is then attributed to Citicoline’s neuroprotective property. It acts by preventing toxins and harmful compounds from damaging the brain. Moreover, this protection is potentiated by increasing the metabolism of phospholipids. Because of this, there would be better neuronal communication and the brain may function more efficiently and effectively. (2)
Citicoline in the medical and research field
Researches and clinical trials are being conducted at the present to determine Citicoline’s benefits towards individuals suffering from cognitive impairment. The good news is that some results showed that it can actually be a potential treatment for traumatic brain injury, Alzheimer’s disease, dementia, and other age-related cognitive decline. Aside from that, Citicoline has been used for the prevention and treatment of cerebrovascular disease or stroke, specifically that of the ischemic type. (5)
How do I maximize the effects of Citicoline?
1. Proper Citicoline dosage and frequency
It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Citicoline, how much of it do we really need each day? Although there have been a wide range of doses available for Citicoline ranging from 250 mg to 2 g per day, it is generally recommended to be taken between 250 mg to 500 mg. You may take it with one or two administrations a day only since it has a relatively long half-life of 60 to 70 hours (2). Also, you may not want to take Citicoline later during the day so as not to interfere with your sleeping patterns due to the energy it provides. (1)
However, it would be best to start with the lowest possible dose yielding the desired effects. Also, it is imperative for you to see and observe how you personally react to the drug, especially if you are a first-timer. Moreover, some people may also need to consult their healthcare provider first for their suggested Citicoline dosage and frequency since their condition and health status may play a role when taking some medications.
2. Stacking Citicoline
Stacking has been a popular practice nowadays. This is done for the purpose of maximizing a drug’s potential and also, in order to yield more positive effects, to synergize each other, or to eliminate or minimize the side effects that the drugs may provide. With the case of Citicoline, what other drugs and supplements may go well with it? A popular and effective stack would involve a Racetam and a Choline source like for example, the Citicoline and Pramiracetam stack. Being a racetam, Pramiracetam requires a good source of Choline to supply it with an increased level of Acetylcholine in the brain for it to efficiently deliver its results. With Citicoline at hand, it supplies a sustained quality source of Choline needed by Pramiracetam. With this combination, Citicoline potentiates and enhances the effect of Pramiracetam. Moreover with the addition of a choline source, headaches, which is a common side effect of Racetams, may be minimized and prevented. This is because headaches occur due to a deficient supply of Acetylcholine in the brain.
When stacking, it is important to note the proper dosage or ratio for both supplements. Like for example in taking Pramiracetam with Citicoline, some researchers suggest a ratio of 2:1 given 2 being the Racetam drug and 1 being the Choline source (4).
Aside from Pramiracetam, Citicoline may also be stacked with other potent nootropics such as that of Noopept, Adrafinil, and among many others.
However when stacking supplements, it would be important if you have a thorough understanding of the drugs since some might not go well with others. It would still be best to consult your doctor or healthcare provider first.
Your favorite powerful nootropics are now available at the market today and can easily be purchased over the internet. Some sources where you may purchase your Citicoline include Amazon.com, PowderCity.com, and among many others. It is available over the counter meaning to say, you do not need any prescription from your doctor in order to purchase one. Citicoline powder and capsule form is available to purchase online and can also be administered intravenously. Citicoline tablets typically come in 500 mg dosages and is the preferred form because it can be taken conveniently, hassle-free. On the other hand, you may also buy Citicoline powder in bulk orders if you wanted to save more from your money. It is water soluble meaning to say, you need not to take it with meals to be absorbed efficiently and can just go along with water. Choosing what’s best for you greatly depends on your personal preferences and both forms delivers the same benefits. (1)
(1) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695184/ (2) http://www.braintropic.com/nootropics/cdp-choline/ (3) http://www.news-medical.net/health/Dopamine-Functions.aspx (4) https://en.wikipedia.org/wiki/Meclofenoxate (5) stroke.ahajournals.org/content/30/12/2592.full
Reviewer: Kathleen R. RN, PT
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Wiki Last Updated: 2016-12-04
Citicoline (CDP-Choline) Dosage
A few reported side effects of Citicoline use are generally mild and includes headaches, diarrhea, nausea, insomnia, and other gastrointestinal problems.
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